Marplan online prescriptions

Marplan works by blocking 2 types of monoamine oxidase (specifically, MAO-A and MAO-B). These enzymes break down neurotransmitters like serotonin, norepinephrine, and dopamine in the brain. By preventing this breakdown, Marplan raises the levels of these neurotransmitters, which can alleviate depressive symptoms. Higher levels of serotonin, norepinephrine, and dopamine are thought to improve mood, emotional processing, and mental focus.

It can take 3 to 4 weeks before you start to feel Marplan’s effects. A clinical trial reported that 92% of individuals taking Marplan experienced significant symptom improvement of anxiety at week 3 of treatment and depression at week 4. 

and up. It’s usually not the first choice of medication in individuals newly diagnosed with depression due to the potential for serious side effects. It’s most commonly prescribed when other antidepressants haven’t worked.

Marplan is sometimes prescribed off-label, meaning used for something it’s not FDA-approved for, for anxiety and panic associated with depression.

According to drugs.com, with its discount, the cost of 100 10-milligram tablets of Marplan is $531.51. 

The maker of Marplan, Validus Pharmaceuticals LLC, offers a savings plan that lets eligible people pay as little as $20 and save $100, $150, or $200 on their co-pay for a 30-, 60-, or 90-day prescription. You can also save up to 80% with a prescription or drug discount card from SingleCare Rx, NeedyMeds, drugs.com, GoodRx, WellRx, or other providers, whether or not you have insurance.

Newer antidepressants, like SSRIs, such as Zoloft (sertraline), Lexapro (escitalopram), or Prozac (fluoxetine), or norepinephrine-dopamine reuptake inhibitors (NDRIs) like Wellbutrin (bupropion) are often prescribed for depression before Marplan because they have fewer side effects, no food restrictions and fewer drug interactions in the case of SSRIs, making Marplan a “second-line” treatment for depression. 

Marplan is especially effective for people who didn’t respond to other treatments because it works in multiple ways, whereas SSRIs only work in 1 way. SSRIs only prevent serotonin reuptake to increase serotonin levels in the brain. MAOIs block monoamines to prevent the breakdown of serotonin, norepinephrine, and dopamine — making all 3 more available. 

A clinical review reported that while SSRIs have fewer side effects, they can be slower to work and less effective for the physical symptoms associated with depression when compared to MAOIs. 

Tricyclic antidepressants, like amitriptyline, may be less effective than MAOIs for early-stage treatment-resistant depression. A study reported that MAOIs were more effective than TCAs, with significantly better end-of-treatment scores. 

Atypical antipsychotics, like Rexulti (brexpiprazole), are sometimes prescribed for treatment-resistant depression. Rexulti works by helping balance serotonin and dopamine in the brain. It’s a partial agonist that binds to receptors in the brain and activates them, but not all the way. Unlike SSRIs, it adapts to the brain’s needs, stimulating receptors if there’s a deficit or dampening them if there is too much. Unlike Marplan, which is often used alone, Rexulti is frequently used in combination with medications to treat depression.

Zoloft, Lexapro, Prozac, and Wellbutrin are approved for major depressive disorder (MDD), while Zoloft and Prozac are also approved for OCD and panic disorder. Wellbutrin is additionally approved for seasonal affective disorder (SAD) and smoking cessation. Rexulti and Prozac are approved for adjunctive treatment (alongside another medication) for depression. Zoloft and Lexapro are both approved for anxiety-related conditions, including generalized anxiety disorder (GAD) and social anxiety disorder. Rexulti is approved for schizophrenia, while amitriptyline is approved for depression but is commonly used off-label for chronic pain, migraines, and insomnia.

Zoloft, Lexapro, Prozac, Rexulti, amitriptyline, and Wellbutrin can cause side effects, some of which may be serious. Possible side effects include, but aren’t limited to, restlessness, nausea, dizziness, sexual dysfunction, dry mouth, fatigue, constipation,  insomnia, sweating, blurred vision, headache, and weight changes.

The best way to find out which mental health medication, if any, is best for you, is to talk to a licensed healthcare provider.