Lexapro is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI), that works by increasing serotonin levels in your brain. It’s approved and effective for treating major depressive disorder (MDD) and generalized anxiety disorder (GAD).
Discover if Lexapro is the right medication for your anxiety or depression symptoms and start feeling better. Find a qualified provider on Klarity Health today.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Providers on Klarity Health are independent practitioners with clinical autonomy; a diagnosis, treatment, or prescription is not guaranteed.
Lexapro (escitalopram) is in a class of drugs called antidepressants. More specifically, it’s a selective serotonin reuptake inhibitor (SSRI). It works by increasing the levels of serotonin, a brain chemical responsible for regulating mood, sleep, and more.
The U.S. Food and Drug Administration (FDA) approved brand-name Lexapro in 2002 to treat major depressive disorder (MDD) in people 12 and older and generalized anxiety disorder (GAD) in people 7 and older.
Lexapro is sometimes used off-label (not approved for) in the treatment of other mental health conditions, like social anxiety disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).
The active ingredient in Lexapro is escitalopram, which is also the name of its generic medication. Generic escitalopram was FDA-approved in 2012.
Brand-name Lexapro is available as a tablet. Generic escitalopram is available as a tablet and oral solution. A transdermal patch is the newest formulation of escitalopram. It’s still in the patent phase and not yet on the market. The patch, when available, will provide continuous dosing to eliminate the spikes and drops that can occur with oral doses. It may also be easier to use for people who don’t want to take oral medication every day and adhere to using escitalopram.
Lexapro is an SSRI that works by increasing serotonin levels. When serotonin is released in your brain, it enhances mood, regulates appetite, helps promote sleep, and more. It’s then reabsorbed by your nerve cells. The mechanism of action for Lexapro involves blocking the reabsorption of serotonin, so your brain can continue to use this chemical messenger.
Lexapro is known as a highly selective SSRI. That means it blocks the reuptake of serotonin without significantly affecting other neurotransmitters. This can result in fewer side effects and better tolerance.
Research shows that escitalopram may be more effective than other antidepressants, like Paxil (paroxetine) and Zoloft (sertraline). Lexapro is also widely used because it’s generally well-tolerated and effective at reducing symptoms of anxiety and depression.
Lexapro is FDA-approved to treat generalized anxiety disorder (GAD) in people 7 and older and major depressive disorder (MDD) in adults and adolescents 12 and older.
Because Lexapro is effective at reducing symptoms of depression, anxiety, and more, if your provider believes that it may help alleviate other symptoms, they can prescribe it off-label for conditions like PTSD, OCD, panic disorder, or social anxiety disorder.
Even though Lexapro is generally well-tolerated, there may be cases where your provider may be cautious. For example, if you’re pregnant, planning to become pregnant, or breastfeeding.
Additionally, if you have liver or kidney impairment or a history of seizures, your provider will closely monitor your progress and side effects, and adjust your doses of Lexapro as needed.
To get a Lexapro prescription online, you need to see a board-certified, licensed healthcare provider. Examples of qualified professionals who can give you an online Lexapro prescription online or in person include psychiatrists and medical doctors (MDs), nurse practitioners (NPs), psychiatric nurse practitioners (PMHNPs), and physician assistants/associates (PAs).
A licensed provider will evaluate your symptoms and share treatment options. If they determine that Lexapro or another antidepressant medication is a medically necessary part of a treatment plan for you, they can send a prescription to your preferred pharmacy.
If you need a provider, find one on Klarity Health and often have an online appointment in as little as 24 hours.* On Klarity Health, you don’t need insurance and will never run into hidden fees. And providers on Klarity Health are committed to patient-centered care.
Lexapro is available as a tablet in doses of 5-, 10-, and 20-milligrams. Escitalopram is available in tablet form or as an oral solution. Escitalopram tablets are also available in doses of 5-, 10-, and 20-milligrams. The oral solution contains 1 milligram per milliliter of escitalopram oxalate.
The escitalopram patch isn’t yet available.
If you and your provider decide that Lexapro or escitalopram is medically necessary to help manage your anxiety or depression, they’ll likely start you on a low dose. For adults and adolescents, a starting dose of Lexapro is 10 milligrams daily. It can later be increased to 20 milligrams, which is the maximum daily dose.
Lexapro and escitalopram should be stored at room temperature in a dry place away from children, moisture, and heat.
If you miss a dose of Lexapro or escitalopram, take it as soon as you remember unless it’s time for your next dose. Never take 2 doses at once or in a 24-hour period.
Lexapro is generally well-tolerated. But, like other antidepressants, it has the potential for common and serious side effects. Common side effects include nausea, dry mouth, dizziness, diarrhea or constipation, indigestion, fatigue, insomnia, increased sweating, and changes in appetite. These side effects may be mild and subside as your body adjusts to Lexapro.
For some people, side effects, like irritability, agitation, dizziness, and sensory disturbances (for example, electric shock sensations), headache, mood changes, insomnia, or hypomania, may lead to abrupt discontinuation of Lexapro. It’s important to talk to your provider before discontinuing Lexapro to reduce your risk of withdrawal symptoms.
Lexapro can have drug interactions. Tell your doctor if you take monoamine oxidase inhibitors (MAOIs) or other serotonergic drugs (drugs that affect serotonin levels). Too much serotonin in your system can lead to a potentially life-threatening condition called serotonin syndrome. If you experience symptoms like confusion, rapid heartbeat, muscle stiffness, or agitation, seek medical treatment immediately.
Lexapro can also interact with triptans, other medications that impact the central nervous system, alcohol, and medications that interfere with hemostasis (a physiological process that stops bleeding after an injury) like non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and warfarin.
Before starting Lexapro, let your provider know if you take any of the following medications: cimetidine, digoxin, lithium, pimozide, Celexa, theophylline, carbamazepine, triazolam, ketoconazole, ritonavir, metoprolol, CYP34A inhibitors, or drugs metabolized by cytochrome Also, let your provider know if you are over 60 and have low blood sodium. In each of these cases, your provider will want to monitor how you adjust to and tolerate Lexapro.
The FDA issued a boxed warning for SSRIs, including Lexapro. There’s an increased risk of suicidal thoughts and behaviors in children and young adults who take Lexapro. If you notice new or worsening suicidal thoughts or behaviors, seek help and notify your provider immediately.
If you use Lexapro or generic escitalopram and have any side effects, work with your provider and consider reporting negative side effects to the FDA by visiting MedWatch or calling 1-800-FDA-1088.
A supply of 100 5-milligram tablets could cost $1,544.55, according to drugs.com and with its discount. A 20-milligram supply of 100 tablets could cost $1,684.30.
Escitalopram, the generic medication, is more affordable. It’s available as an oral solution and tablets. For the oral solution, 5 milligrams may cost around $69.16. A supply of 30 5-milligram tablets costs around $14.36, while 10-milligram tablets could cost $14.59. Costs are with the drugs.com discount.
The prices here are what you could pay for Lexapro before insurance. To help save money on Lexapro, look for drug discount and prescription savings cards. You can find them on drugs.com, GoodRx, WellRx, NeedyMeds, and SingleCare Rx and can use them with or without insurance.
Other well-known antidepressants used to treat anxiety and depression include Prozac (fluoxetine), Zoloft (sertraline), and Cymbalta (duloxetine). Like Lexapro, Zoloft and Cymbalta are FDA-approved to treat depression and anxiety. Prozac is approved to treat MDD, obsessive-compulsive disorder, bulimia, binge eating disorder, premenstrual dysphoric disorder, and bipolar depression in some cases.
The common side effects for Lexapro, Zoloft, Cymbalta, and Prozac are similar. People taking these antidepressants may experience nausea, dry mouth, insomnia, drowsiness, and diarrhea.
When compared to other antidepressants on the market, like Paxil (paroxetine) and Zoloft (sertraline), Lexapro has been shown to be more effective.
A systematic review and meta-analysis found that escitalopram, when compared to other antidepressants like Cymbalta (duloxetine), Celexa (citalopram), Prozac (fluoxetine), and Paxil (paroxetine), Lexapro was more effective at alleviating acute symptoms of MDD. Lexapro was also better tolerated.
The best way to find out which depression medication is best for you, if any, is to talk to a provider who specializes in treating depression. If you need a provider, you can find one on Klarity Health and often have an appointment in as little as 24 hours.*
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Providers on Klarity Health are licensed, board-certified, and offer a personalized approach to your unique mental health needs. See detailed profiles for each provider and find an approach that’s best for you. (Costs for treatment options may vary.)
Your journey to reduced depression starts with an initial consultation Your provider will go over your goals and medical history to recommend a treatment plan that’s right for you and that may or may not include prescription medication.
Your initial consultation is just the beginning. You and your provider will follow up to make sure you’re doing okay and that you’re reaching your goals. You stay on track with easy medication refills and ongoing support from your provider.
If you have questions or need assistance, the friendly Klarity Health Patient Support team is here to help. Along with your provider, they’re committed to making sure you have the best care and support throughout your journey.
Klarity Health connects you with experienced, licensed providers who specialize in mental health treatment. Select your state to see available providers.
*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.
The information provided in this article is for educational purposes only and should not be construed as medical advice. Controlled substances may not be appropriate for all patients and any mention of these medications is for educational purposes only, not for marketing or encouraging self-diagnosis. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.
If you’re having a mental health crisis or experiencing a psychiatric emergency, it’s crucial to seek immediate help from a mental healthcare professional, such as a psychiatrist, psychologist, or therapist. You can also call your local emergency services, visit your nearest emergency room, or contact a crisis hotline, such as the National Suicide Prevention Lifeline, by calling or texting 988 or dialing the Lifeline’s previous phone number, 1-800-273-TALK (1-800-273-8255) in the U.S.