If you have depression or anxiety, you may be considering selective serotonin reuptake inhibitors (SSRIs) to effectively treat your symptoms. Choosing the right medication can be a challenge, especially since many of them have similar effects on the body and mind.

This comparison guide will show you the similarities and differences between two popular SSRI medications—Viibryd and Luvox—to help you choose the best depression treatment.

When deciding which medication is right for you, you should always consult with a medical professional. If you don’t have access to a reliable psychiatrist or have adequate insurance coverage, Klarity Health can help. We’ll match you with a licensed healthcare provider in your state for convenient and affordable online depression or anxiety treatment.

Your provider on Klarity Health will evaluate your symptoms and prescribe an SSRI like Viibryd or Luvox if they determine it is right for you. Schedule an appointment on Klarity Health today and be seen by a provider within 48 hours.

	Viibryd	Luvox
Drug Class	Selective serotonin reuptake inhibitor (SSRI)	Selective serotonin reuptake inhibitor (SSRI)
Brand / Generic Status	Brand name for vilazodone	Brand name for fluvoxamine
Form(s) of the Drug	Immediate release, color-coded tablets	Immediate release tablets, Extended-release capsules
Standard Dosage	Color-coded immediate release tablets: • 10mg red • 20mg yellow • 40mg blue	Tablets: • 25 mg • 50 mg • 100 mg Extended-release capsules: • 100 mg • 150 mg
Conditions Treated	FDA-approved uses: • Depression Off-label uses: • Obsessive-compulsive disorder • Generalized anxiety disorder • Panic disorder	FDA-approved uses: • Obsessive-compulsive disorder (OCD) Off-label uses: • Social phobia or social anxiety disorder (SAD) • Major depressive disorder (MDD) • Generalized anxiety disorder (GAD) • Post-traumatic stress disorder (PTSD) • Panic disorder • Eating disorders
Cost	Generic form (vilazodone): • $15 for a 30-day supply Brand-name: • $340 for a 30-day supply	Generic form (fluvoxamine): • $20 to $46 for a 30-day supply Brand-name: • $400 for a 30-day supply
Side-Effects	Common side effects: • Nausea • Vomiting • Diarrhea • Insomnia • Sexual dysfunction Serious side effects: • Seizures • Blurred or tunnel vision • Eye pain, swelling, or seeing halos around lights • Easy bruising or unusual bleeding • Racing thoughts or unusual risk-taking behavior • Decreased inhibitions, euphoria, or extreme sadness • Headache or severe weakness • Confusion or slurred speech • Loss of coordination or feeling unsteady	Common side effects: • Dry mouth • Fatigue, dizziness • GI upset, including abdominal pain, nausea, vomiting, diarrhea, or constipation • Headache • Difficulty sleeping or insomnia • Increased anxiety or nervousness • Increased or excessive sweating Serious side effects: • Trouble urinating • Breathing problems • Sexual dysfunction, including lack of desire or orgasm
Warnings For Use	Contraindicated conditions: • Liver or kidney disease • Bleeding or blood clotting disorders • Narrow-angle glaucoma • Epilepsy • Bipolar disorder • Sexual function issues • A history of drug addiction • Suicidal thoughts Drug interactions: • Monoamine oxidase inhibitors (MAOIs) • Pimozide or other Tourette's syndrome medications • Thioridazine or other antipsychotic medications • Stimulant medications, like Adderall • Opioid-based painkillers • Herbal supplements, such as St. John’s Wort • Tryptophan	Contraindicated conditions: • Liver disease • Prior heart attack or severe heart disease • Heart arrhythmias • Bipolar disorder or prior episodes of mania • Seizure disorder Drug interactions: • Monoamine oxidase inhibitors (MAOIs) • NSAID medications, including ibuprofen • Warfarin and other blood-thinning medications • Other SSRI medications and antidepressants • ADHD medication, like Adderall • St. John’s Wort • Most pain medications, including opioids • Thiazide diuretics • Recreational drugs, such as MDMA

What is Viibryd?

Viibryd is the brand name for the SSRI medication vilazodone. SSRIs help regulate brain chemistry by blocking serotonin receptors and increasing serotonin levels in the brain, which helps regulate a patient’s mood, energy levels, sleep cycles, and appetite.

Common Doses and Forms of Viibryd

Viibryd comes in color-coded oval tablets with the dosage printed on one side.

10mg red
20mg yellow
40mg blue

Most individuals start Viibryd by taking 10mg and gradually increasing their dosage to the maximum dosage of 40mg, if necessary. Viibryd should be taken once daily with food.

Conditions Viibryd Treats

Viibryd is only FDA-approved to treat Major Depressive Disorder (MDD), otherwise known as chronic depression. However, it’s often prescribed off-label to treat anxiety and anxiety-related disorders and conditions.

Off-Label Uses for Viibryd

Off-label refers to the practice of prescribing medications to treat conditions not approved by the FDA. These medications are considered safe to take; they just haven’t gone through the FDA approval process for every condition they’re able to treat.

For instance, Viibryd is often prescribed off-label for the following:

Obsessive-compulsive disorder
Generalized anxiety disorder
Panic disorder

Viibryd Can Treat Symptoms of Depression and Anxiety

Bringing brain chemistry into balance is one of the most effective ways to treat depression and anxiety. Low serotonin levels can cause opposing symptoms, such as:

Extreme fatigue or manic nervousness
Apathy or panic attacks
Extreme exhaustion or insomnia
Disinterest in food or nervous nausea

Each set of symptoms can result from depression and/or anxiety. Raising serotonin levels in the brain helps reset its natural rhythms and reactions to alleviate these symptoms.

Viibryd Costs

Brand name Viibryd costs much more than generic vilazodone. They’re the same medication with different branding, so it’s more cost-effective to ask for the generic prescription, especially if you don’t have adequate health insurance.

For instance, 30 days’ worth of Viibryd can cost over $340, while the same amount of vilazodone costs around $15.

Viibryd Side Effects

Viibryd has fewer side effects than most other SSRIs, meaning many patients tolerate it better than other drugs in the same class. Some of its common side effects include:

Nausea
Vomiting
Diarrhea
Insomnia
Sexual dysfunction

Less common but more serious side effects may arise if you develop a condition called serotonin syndrome, which is potentially fatal. This condition occurs when your brain is overloaded with serotonin. If you experience any of the following symptoms, seek medical attention immediately:

Seizures
Blurred or tunnel vision
Eye pain, swelling, or seeing halos around lights
Easy bruising or unusual bleeding
Racing thoughts or unusual risk-taking behavior
Decreased inhibitions, euphoria, or extreme sadness
Headache or severe weakness
Confusion or slurred speech
Loss of coordination or feeling unsteady

Viibryd Warnings

People with certain conditions should not take Viibryd because it could make those conditions worse or interact with the medications used to treat them. These conditions include:

Liver or kidney disease
Bleeding or blood clotting disorders
Narrow-angle glaucoma
Epilepsy
Bipolar disorder
Sexual function issues
A history of drug addiction
Suicidal thoughts

Viibryd Drug Interactions

Some medications may interact poorly with Viibryd and create an increased risk of serious health problems. Those who take the following medications should avoid taking Viibryd:

Monoamine oxidase inhibitors (MAOIs)
Pimozide or other Tourette’s syndrome medications
Thioridazine or other antipsychotic medications
Stimulant medications, like Adderall
Opioid-based painkillers
Herbal supplements, such as St. John’s Wort
Tryptophan

What is Luvox?

Luvox is the brand name for an SSRI medication called fluvoxamine. Similar to Viibryd, Luvox boosts serotonin levels in the brain by preventing certain receptors from transferring it to the bloodstream. This process helps relieve the symptoms of depression, anxiety, and other conditions related to mood and brain chemistry.

Common Doses and Forms of Luvox

Both brand name Luvox and generic fluvoxamine are white tablets that come in a blister pack. Brand name Luvox tablets are oval, while fluvoxamine is round. Each kind is available in the following dosages:

25mg
50mg
100mg

When taking Luvox, you can choose between immediate-release (IR) tablets or extended-release (ER) capsules. Adults over 18 typically start on 50mg and can gradually increase their dose over several weeks up to 300mg per day, if needed.

Conditions Luvox Treats

Luvox is effective for treating an array of conditions related to depression and anxiety. It’s only FDA-approved to treat obsessive-compulsive disorder (OCD) but has several off-label uses, including depression.

Off-Label Uses for Luvox

Because it’s effective in treating OCD, Luvox is often prescribed off-label for other anxiety-related mental health conditions, including:

General anxiety
Panic disorder
Social phobias
Eating disorders
Borderline personality disorder (BPD)

Luvox Can Treat Symptoms of OCD and Depression

Though depression and OCD may sometimes be exacerbated by stressful environments or events, SSRIs like Luvox can help alleviate symptoms of these disorders by regulating serotonin production.

Symptoms of OCD include:

Intense, unreasonable fear
Racing and intrusive thoughts
Difficulty tolerating uncertainty
Requiring order and symmetry to feel safe

Symptoms of depression include:

Extreme fatigue
Apathy or listlessness
Loss of appetite
Insomnia
Lack of interest

Luvox Costs

Pricing for brand name Luvox varies from $32 to over $400 for a month’s supply. The generic version, fluvoxamine, costs between $25 and $30 for the same amount.

Luvox Side Effects

Luvox has more known side effects than Viibryd. However, many are mild and dissipate after a few weeks. Some of the most common side effects include:

Feeling dizzy, weak, sleepy, or tired
Constipation, stomach pain, nausea, vomiting, diarrhea, or reduced appetite
Dry mouth or change in taste
Insomnia
Headache or shakiness
Excess gassiness
Feeling nervous and easily startled
Excessive sweating
Common cold symptoms

The following symptoms may indicate an allergic reaction to Luvox or other serious health complications:

Allergic reaction, including hives; swelling of the face, mouth, and throat; difficulty breathing
Signs of low sodium, including headache, brain fog, weakness, seizures, or trouble balancing
Coughing up or vomiting blood; blood in the urine or stool; unusual vaginal bleeding; bleeding that cannot be easily stopped
Abnormal weight gain or loss
Difficulty passing urine
Sexual problems, such as difficulty orgasming or lowered sex drive
- Erection lasting more than 4 hours
Unusual menstrual flow

Like Viibryd, Luvox may also cause serotonin syndrome. If you experience the symptoms of this syndrome listed above, seek medical attention immediately.

Luvox Warnings

Luvox and other SSRIs may cause adverse reactions in those with the following conditions:

Bipolar disorder
Bleeding problems
Depression
Glaucoma
Heart attack or heart disease
Heart rhythm problems
Hyponatremia (low sodium in the blood)
Mania (feeling elated)
Seizures
Liver disease
Habitual tobacco use

Luvox Drug Interactions

Adverse drug interactions can cause serious health complications. If you take any of the following medications, you should consider alternatives to Luvox:

Monoamine oxidase inhibitors (MAOIs)
Tourette’s syndrome medications, like pimozide
Warfarin and other blood thinners
Ibuprofen and other NSAIDs
St. John’s Wort
Tryptophan
Other SSRIs and antidepressants
Stimulant medications like Adderall
Certain pain or migraine medications

Speak to a Healthcare Provider On Klarity Health in 24 Hours*

Your provider on Klarity Health will evaluate your symptoms via a private telehealth appointment and may prescribe an antidepressant like Viibryd or Luvox if they determine one to be the best treatment for you. Find your provider today to get started.

Frequently Asked Questions About Viibryd and Luvox

Does Viibryd Make You Gain Weight? Does Luvox?: Neither Viibryd nor Luvox typically causes weight gain. However, if your appetite returns because you’re taking one of these medications, eating more regularly could cause some weight gain.
Is Viibryd or Luvox Better for Anxiety?: Viibryd is more commonly prescribed to treat anxiety because it’s better tolerated than many other SSRIs and significantly alleviates symptoms. However, Luvox is FDA-approved to treat OCD, an anxiety-related condition, so it could also be effective in treating anxiety.
Can I Replace Viibryd with Luvox?: Yes, you can replace Viibryd with Luvox, provided you do so under medical supervision. Your healthcare provider will either taper you off Viibryd completely and replace it with a low dose of Luvox or taper you off Viibryd while simultaneously taking low doses of Luvox. After the Viibryd is out of your system, you’ll gradually increase your dose until you reach the recommended amount.
Is Viibryd Energizing or Sedating? What About Luvox?: Both medications may cause daytime drowsiness. However, other changes in energy levels depend on why you’re taking the medication. Those taking an SSRI for depression may feel energized, while those taking it for OCD or panic disorder will probably feel calmer and more relaxed.
Does Viibryd Cause Brain Fog? Does Luvox?: The risk of daytime sleepiness and fatigue may cause mild brain fog. However, sudden onset or worsening brain fog may be a serious side effect that requires immediate medical attention.
Can I Drink Alcohol On Viibryd? On Luvox?: No it’s never safe to drink alcohol while taking an SSRI. Alcohol enhances the medication’s effects, posing very serious health risks.
Can I Drink Caffeine When I’m on Viibryd? How About Luvox?: Yes, caffeine doesn’t interact adversely with SSRIs, so you can enjoy caffeinated coffee, tea, and other beverages. However, limiting your intake could help the medication work better if you’re taking one of these medications for anxiety.
Viibryd or Luvox: Which One is Right for You?: While both Viibryd and Luvox are antidepressant medications, Luvox is only FDA-approved to treat OCD. However, its lack of FDA approval does not mean it is an unsafe medication, and it is frequently prescribed off-label by healthcare professionals to treat depression.

Despite both of these medications being SSRI antidepressants, each one has a unique ability to treat mental health conditions. Additionally, Viibryd and Luvox have their own side effects and contraindications with other medications and conditions.

For these reasons, you should never attempt to self-medicate. In order to safely determine which prescription medication is right for you, speak with a medical professional.

Sources: https://www.drugs.com/viibryd.html#dosage

https://www.rxlist.com/viibryd-drug.htm#description

https://www.rxlist.com/luvox-drug.htm

https://www.drugs.com/sfx/luvox-side-effects.html
How we reviewed this article: This article went through rigorous fact-checking by a team of medical reviewers. Reviewers are trained medical professionals who ensure each article contains the most up-to-date information, and that medical details have been correctly interpreted by the author. Learn more about the editorial and medical review process and standards for the HelloKlarity site.

*Appointments are generally available within 24 hours. Free initial consultations are available only with select providers. Prescriptions, particularly for controlled substances, may require an in-person evaluation depending on the state of residence and current federal regulations.

The information provided in this article is for educational purposes only and should not be construed as medical advice. Controlled substances may not be appropriate for all patients and any mention of these medications is for educational purposes only, not for marketing or encouraging self-diagnosis. Always seek the guidance of a qualified healthcare professional with any questions or concerns you have regarding your health. Providers on Klarity Health are independent practitioners with clinical autonomy. Nothing in this article is intended to diagnose or treat any condition, including guaranteeing prescription medication of any kind or dosage. Not all providers on Klarity Health prescribe all medications, particularly medications that are controlled substances.

If you’re having a mental health crisis or experiencing a psychiatric emergency, it’s crucial to seek immediate help from a mental healthcare professional, such as a psychiatrist, psychologist, or therapist. You can also call your local emergency services, visit your nearest emergency room, or contact a crisis hotline, such as the National Suicide Prevention Lifeline, by calling or texting 988 or dialing the Lifeline’s previous phone number, 1-800-273-TALK (1-800-273-8255) in the U.S.